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Moderate alcohol consumption as risk factor for adverse brain outcomes and cognitive decline: longitudinal cohort study. Study design and participants. Five hundred and fifty people were randomly selected for the current Whitehall II imaging substudy (2. Whitehall II cohort study. The Whitehall II study was established in 1. University College London, with the aim of investigating the relation between socioeconomic status, stress, and cardiovascular health. It recruited 1. 0 3. Sociodemographic, health, and lifestyle variables (including alcohol use) were measured over a follow- up period of about 3. High Energy Fat Burner - Vegan Diet For Weight Loss Meal Plan Pdf High Energy Fat Burner Weight Loss Supplements During Pregnancy Weight Loss Clinic Johnson City Tn. Stair stringer calculator free download. Samsung PC Studio 7.2.24.9 41,850 downloads: Nero 9 Free 9.4.12.3d 33,427 downloads. Net, Free downloads of Stair Calculator. Advance your online legal research with Westlaw, the most preferred service year after year. Start your Free Trial today. For prevention and management of diabetes complications in children and adolescents, please refer to Section 12 “Children and Adolescents.” Atherosclerotic. ![]() The 3638323 to 1605548 a 1450464 of 14434154 in 1270284 on 508384 that 503295 is 492114 said 487849 with 423779 at 408185. The Best Practice Advocacy Centre delivers educational and continuing professional development programmes to medical practitioners and other health professional. To make the sample as representative as possible of the cohort at baseline, we drew a random list of 1. Whitehall II phase 1. Participants were sampled from high, intermediate, and low socioeconomic groups. Alcohol variables collected in each phase included units drunk a week, frequency of drinking a week over the previous year, and results of the CAGE screening questionnaire. We used weekly consumption in this analysis as there is less likelihood of a ceiling effect in comparison with drinking frequency. We calculated average alcohol use across the study as mean consumption a week averaged across all study phases. Participants were deemed “abstinent” if they consumed less than 1 unit of alcohol a week. Social class was determined according to occupation at phase 3 (highest class=1, lowest=4).
Drugs (number of psychotropic drugs reported as taken) and lifetime history of major depressive disorder (assessed by structured clinical interview for DSM IV) were assessed at the time of the scan. Information about personality traits was determined by questionnaire at phase 1 and included trait impulsivity (question: “Are you hot- headed?”). Cognitive function was assessed longitudinally at phases 3, 5, 7, 9, and 1. Short term memory recall (2. Cross sectional cognitive performance was measured at the time of the scan with the Montreal cognitive assessment (Mo. CA, education adjusted), trail making test (TMT- A and B), Rey- Osterrieth complex figure (RCF) test (copy, immediate, delay, recognition), Hopkins verbal learning test (HVLT- R; immediate, delay), Boston naming test (BNT), and digit span and digit substitution test (DSST). Full scale IQ (FSIQ) was estimated at the time of the scan with the test of premorbid functioning- UK version (TOPF- UK), with adjustment for sex and education. Participants were included in the imaging substudy if they were safe to undergo MRI and able to give informed consent. Exclusions were due to incomplete or poor quality imaging data or gross structural abnormality (such as a brain cyst), incomplete data on alcohol use (> 2 study phases data missing), and missing sociodemographic, health, or cognitive data (fig 2. We used T1- weighted and diffusion tensor (DTI) 3. T MRI sequences for these analyses. Full technical details are in the appendix. In brief, we initially examined associations between alcohol use and grey matter using voxel based morphometry, an objective method to compare grey matter density between individuals in each voxel (smallest distinguishable image volume) of the structural image. For each participant for subsequent analyses we additionally extracted hippocampal volumes (adjusted for total intracranial volume) using an automated segmentation/registration tool. Automated segmentation of the amygdala was less reliable in this sample so we did not use extracted volumes in this analysis. Three clinicians independently defined hippocampal atrophy according to visual rating (Scheltens score. Diffusion tensor images indicate the directional preference of water diffusion in neural tissue and allow inferences about the structural integrity of white matter tracts. In healthy myelinated fibres diffusion is restricted perpendicular to the longitudinal axis of the fibre—that is, it is anisotropic. We carried out voxel- wise statistical analysis of diffusion tensor data (fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD)) using tract based spatial statistics (TBSS). Outcomes. Primary outcomes were continuous measures of grey matter density in the voxel based morphometry analysis and white matter integrity in the tract based spatial statistics analysis (fractional anisotropy, mean, radial, and axial diffusivity). Visual ratings of hippocampal atrophy were dichotomised into atrophy versus no atrophy based on 0/1 on the (4 point) Scheltens scale to reflect clinical use (“abnormal” versus “normal”). Hippocampal volume (%intracranial volume) was used as a continuous variable in a multiple linear regression analysis. As cognitive outcomes we used decline in short term memory, semantic and lexical fluency, and cross sectional performance on Montreal cognitive assessment, trail making test, Rey- Osterrieth complex figure test, Hopkins verbal learning test, Boston naming test, digit span, and digit substitution test. Statistical analysis. All analyses were done with R,3. To assess representativeness of included participants we examined differences between included and excluded participants using t tests of means (continuous variables) or . According to variable type, we used means (standard deviations), medians (interquartile ranges), or numbers (percentages) to summarise sociodemographic and clinical measures for included participants who were split by safe versus unsafe average alcohol use averaged over all phases, on the basis of UK contemporary (pre- 2. Significant differences between safe and unsafe drinkers in continuous variables were tested with t tests of means (normally distributed) or Wilcoxon rank sum tests (non- normally distributed), and in binary categorical variables (and mini- mental state examination, Montreal cognitive assessment, and Framingham stroke risk score, which have lower and upper bounds) with Fisher’s exact test of proportions. In view of small group numbers (< 5) for social class, we performed a simulation test to estimate group differences. Weekly consumption of alcohol (units and grams) was described with means, standard deviations, medians, and interquartile ranges. We examined alcohol trends over time using mixed effects modelling, with time from study baseline (phase 1) as the independent variable and alcohol consumption (units/week) as the dependent variable. This method accounts for missing data and correlation of repeated measures (in this case alcohol use). We calculated intercepts (baseline consumption) and slopes (trends over study) for each participant. The ability of other variables to predict longitudinal trends of alcohol consumption was tested by inclusion of the following in the mixed effects model: age, sex, education, premorbid IQ, social class, Framingham risk score (a composite measure including smoking, cardiovascular disease or diabetes, cardiovascular drugs), exercise frequency, club attendance, voluntary work, visits with friends and family, lifetime history of major depressive disorder on the structured clinical interview for DSM IV (SCID) (yes- 2/no- 1), and current psychotropic drugs (yes- 2/no- 1). We included mean alcohol consumption (units/week) across all study phases as an independent variable in voxel based morphometry (grey matter density as dependent variable) and tract based spatial statistics analyses (FA/MD/RD/AD as dependent variable). Voxel- wise, we applied a generalised linear model (GLM) using permutation based non- parametric testing (randomise),3. TFCE). 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Free download and pdf download 1973 to 1990 Johnson Evinrude Outboard 2Hp to 40Hp 2 & 4-Stroke Cycle Workshop Service Repair Manual. ENGINE STOPPING ............... REMOTE CONTROLS — EVINRUDE ICON. The more you know and un- derstand about your Evinrude E- TEC outboard, the greater Additionally, Bombardier Recreational Products (BRP) has the safety and pleasure you will get from using it. Following.. IMPORTANT SAFETY MESSAGES This Operator’s Guide contains essential information to Whenever running the engine, assure there is proper help prevent personal injury and damage to equipment. The Maintenance gearcase of this outboard extends below the water surface and could potentially come in contact with underwater obstructions. Contact with underwater The outboard must be correctly installed. Failure to obstructions may result in loss of control and person- correctly install the outboard could result in serious al injury. PRODUCT REFERENCES, ILLUSTRATIONS AND SPECIFICATIONS BRP reserves the right to make changes at any time, without notice, to features, specifications and model availability, and to change any specification or part at any time without incurring any obligation to update older models. The informa- tion in the Guide is based on the latest specifications available at the time of publication. Technical Literature BRP offers technical literature specifically for your outboard. A service manual, a parts catalog, or an extra Operator’s Guide can be purchased from your selling Dealer. For the name and location of the nearest Evinrude Dealer in the United States and Canada visit www. Using Your USING YOUR Evinrude E- TEC Outboard EVINRUDE E- TEC OUTBOARD.. USING YOUR EVINRUDE E- TEC OUTBOARD . Any person who operates this outboard should read All outboards are shipped with the following hang tag at- and understand this safety information. Failure to do so could result in serious injury. Attach engine shut- off cord (Lanyard) to operator. WARNING Shift position Reverse / Neutral / Forward.. USING YOUR EVINRUDE E- TEC OUTBOARD . Evinrude E- TEC outboard. This synthetic formula oil pro- vides uncompromised lubrication and superior perfor- You must use an oil tank equipped with a filter and an oil mance, even in extreme conditions—especially in cold.. Replace the filler cap and tighten securely. Gasoline is extremely flammable and highly explo- Always keep a supply of oil in the tank. USING YOUR EVINRUDE E- TEC OUTBOARD . Refer to the boat’s owner guide. DO NOT run the engine indoors or without adequate You MUST supply water to the engine before attempting to ventilation or permit exhaust fumes to accumulate start it. USING YOUR EVINRUDE E- TEC OUTBOARD . If the engine did not start, release the key momentarily, then try again. WARNING Each time the key switch is turned from OFF to ON, the warning system will self- test. Refer to ENGINE MONITOR- ING on page 3. This feature can prevent injuries resulting from unexpected boat movement when the engine starts. Evinrude ICON is an intelligent, electronic shift and throttle control system for use with ICON equipped outboards. ICON control systems are available for single–.. USING YOUR EVINRUDE E- TEC OUTBOARD . Evinrude controls deliver the cable stroke your outboard needs for positive shift and throttle control, and they incorporate such safety and convenience features as: . WARNING Avoid knocking or pulling the clip off the stop switch during normal boating. When boat reaches top speed, throttle back from FULL SPEED to a lower throttle setting. You will save fuel with a minimal loss of speed. Typical Fuel Economy Throttle Range 1. USING YOUR EVINRUDE E- TEC OUTBOARD . Personal injury or death can result from contact with moving parts of the out- board. Trailering Bracket To engage bracket — Tilt the outboard fully using the tilt switch inside the boat or the trailering tilt switch (on port or starboard side of engine, depending on configuration). USING YOUR EVINRUDE E- TEC OUTBOARD . If you back into an object, either ing ring. Disintegration of the an- vided for use in salt or brackish water. Your speedometer pickup, all water must be cleared from the Evinrude E- TEC outboard uses 1. Refer to STORAGE on page 3. Operating your outboard without an During engine start- up, pause with the key switch in the ON engine monitor will void your warranty for failures related to position. The outboard has approximately five hours (ten hours if using Evinrude/Johnson XD1. NO OIL”.. USING YOUR EVINRUDE E- TEC OUTBOARD . Refer to ture restored. The following chart provides guidelines other high hour applications require more frequent inspec- for inspection and maintenance to be performed by an au- tions and maintenance. MAINTENANCE . DANGER 2) Connect garden hose to flushing port. Turn on the water. It is not necessary to run the engine DO NOT run the engine indoors or without adequate for a good flushing. Start the outboard. Outboard runs at slow idle speed. If you must tilt the outboard to remove it from the water, lower it and allow the cooling system to drain completely as soon as you clear the launch area. MAINTENANCE . Start the outboard. Outboard runs at slow idle speed. Concealed Side Mount Control – Typical Tiller Control – Typical 2) After outboard runs for about 1. After outboard runs for about 1. For side mount controls, lower fast idle lever. If equipped, disconnect the speedometer pickup at the upper connection and blow all water out of the 1) Press foot throttle to HALF THROTTLE position. MAINTENANCE . Incorrect spark plug maintenance can lead to en- gine damage. Prepare your outboard for a season of reliable service by IMPORTANT: Replacement spark plugs MUST be in- performing a general check and a few preventive mainte- dexed correctly. Marine growth or bottom painting may reduce speed and fuel efficiency. Periodically, wash the entire boat and outboard with soapy water and apply a coat of automotive wax. Leave the en- For maximum performance, keep the boat’s running sur- gine cover in place when washing the outboard. MAINTENANCE . Refer to FUSE on page 3. Engine will not start . Refer to ENGINE STARTING on page 1. PRODUCT INFORMATION.. PRODUCT INFORMATION . Counter Rotation Right- hand propellers are considered standard rotation Propeller Selection propellers. When propelling a boat forward, the propeller rotates in a right- hand (clockwise) direction as viewed from the rear. WARNING Left- hand propellers are considered counter rotation pro- pellers. Slide propeller onto shaft, engaging the splines and seat- ing it on the thrust bushing. Slide spacer onto the shaft and engage the propeller shaft splines. Wedge a block of wood between the propeller blade and the anti- ventilation plate. PRODUCT INFORMATION . Noticing changes in wa- lated to prevent their shorting or arcing and causing ter pressure can help prevent engine overheating. The wa- an explosion. A propeller will generate steering torque when the propeller shaft is not running parallel to the water’s surface. The trim tab is adjustable to compensate for this steering torque. IMPORTANT: A single trim tab adjustment will relieve steering effort under only one set of speed, outboard angle and load conditions. PRODUCT INFORMATION . BRP re- serves the right to modify this warranty at any time, being understood that such modification will not alter the warranty.. In cases where the delivery date is not established to BRP’s satisfaction, the date of sale will be used to determine the warranty start date. CONSUMER ASSISTANCE . 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